| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| Apoptosis |
| AT-1009 |
Anti-BID (59/60) Cleavage-Site Specific Polyclonal
Antibody |
BH3 interacting domain death agonist (BID, 22 kDa) is a
pro-apoptotic member of the Bcl-2
family. BID interacts with both Bcl-2 and Bax
through its BH3 domain. It usually exists in an
inactive form in the cytosolic fraction of living cells and becomes cleaved
and activated by
caspase-8 in response to TNF-alpha or Fas ligand. |
polyclonal |
rabbit IgG, affinity purified |
10 blot |
WB |
| AT-1001 |
Anti-BID (p15) Polyclonal Antibody |
BH3 interacting domain death agonist (BID) is a
pro-apoptotic member of the Bcl-2 family. BID
interacts with both Bcl-2 and Bax through its
BH3 domain. It usually exists in an inactive form in the
cytosolic fraction of living cells and becomes cleaved and activated by
caspase-8 in response to TNF-alpha
or Fas ligand. |
Polyclonal |
rabbit IgG |
100 µL |
WB |
| AT-1007 |
Anti-Caspase-9 [315/316] Polyclonal Antibody |
This antibody reacts with the N-terminus of a cleavage
site located between amino acids 315/316 of human
caspase-9. As with all members of the caspase family of proteases,
proteolytic cleavage of procaspase-9 is required for caspase-9 activation. It
has been demonstrated that there are at least two cleavage sites on human
procaspase-9, an autoactivation site at 315/316 and a caspase-3 cleavage site
between residues 330 and 331. Autoactivation of procaspase-9 by cleavage at
site 315/316 is essential for full activation of caspase-9. Cleavage of
procaspase-9 at the autoactivation site produces a 10 kDa fragment. It is the
N-terminus of this fragment, which is recognized by this antibody. |
Polyclonal |
rabbit IgG, Purified |
200 µL |
WB, IHC |
| AT-1003 |
Anti-Cytochrome c Monoclonal Antibody |
This antibody recognizes an epitope within amino acids
93-104. It reacts with denatured Cytochrome c. |
7H8.2C12 |
Mouse IgG2b |
100 µg |
WB |
| AT-1004 |
Anti-Cytochrome c Monoclonal Antibody |
This antibody reacts with native forms of Cytochrome c and
binds to a region around residue 64 of rat
Cytochrome c. |
6H2.B4 |
Mouse IgG1, Kappa |
100 µg |
IP, IHC |
| AT-1002 |
Anti-Fas Ligand Monoclonal Antibody |
This antibody binds to Fas ligand (FasL), also known as
CD95L, a member of the TNF family, and induces
apoptosis via binding to Fas (CD95). FasL is expressed on a variety of cells
including activated lymphocytes, natural killer cells and monocytes. |
ALF1.2 |
Mouse IgG1 |
100 µg |
FC, EA |
| AT-1006 |
Anti-Fas/CD95/Apo-1 Monoclonal, Biotin Conjugated |
Recognizes natural and recombinant human Fas. |
DX-3 |
Mouse IgG2a, Biotin Conjugate |
0.1 mg |
ELISA |
| AT-1005 |
Anti-Fas/CD95/Apo-1 Monoclonal, FITC Conjugated |
Reacts with only a minority of resting peripheral T cells
and B cells. Reacts strongly with activated T
cells, B cells, NK cells and thymocytes. |
DX2+DX3 |
Mouse IgG1 (DX2) and Mouse IgG2a (DX3), FITC Conjugate |
100 µg |
FC |
| AT-1010 |
Anti-PARP [214/215] Polyclonal Antibody |
Poly (ADP-Ribose) Polymerase (PARP) is a 116 kDa nuclear
protein which is strongly activated by binding to
DNA strand breaks. PARP plays a role in DNA repair as well as in other
cellular processes, including DNA replication, cell proliferation and
differentiation. This antibody specifically recognizes the 85 kDa fragment of
cleaved PARP and can be used as a marker for detecting apoptotic cells. |
Polyclonal |
rabbit IgG |
100 µL |
WB, IHC |
| AT-1008 |
Anti-PARP [214/215] Polyclonal, FITC Conjugated |
This antibody specifically recognizes the 85 kDa fragment
of cleaved PARP and can be used as marker for
detecting apoptotic cells. |
Polyclonal |
rabbit IgG, FITC Conjugate |
100 tests |
FC, WB, IHC |
| AT-1011 |
Anti-Phospho-Bad [pS112] Polyclonal Antibody |
This antibody recognizes Bad (Mr=23 kDa) only when
phosphorylated at serine 112. Bad is a member of
the Bcl-2 family and it promotes cell death through heterodimerization with
the survival proteins Bcl-2 and Bcl-xL. Phosphorylation of Bad results in its
cytoplasmic sequestration by the tau form of 14-3-3 proteins and this
abrogates its interaction with Bcl-xL, allowing Bcl-xL to promote survival of
the cell. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-1020 |
Anti-Phospho-Bad [pS128] Polyclonal Antibody |
BAD is a ~23 kDa member of the Bcl-2 family and acts to
promote apoptosis by forming heterodimers with the
survival proteins Bcl-2 and Bcl-xL, thus preventing them from binding with
BAX. BAD is phosphorylated on serine 128 by cdc2 and c-Jun N-terminal kinase
(JNK). JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic
role of BAD by opposing the inhibitory effect of growth factor on
BAD-mediated apoptosis. Cdc2-induced phosphorylation of BAD serine 128 has an
inhibitory effect on its interaction with 14-3-3 proteins. The latter
interaction is critical for BAD phosphorylation at serine 155, a site within
the BH3 domain that leads to the release of Bcl-xL and the promotion of cell
survival. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µg |
WB |
| AT-1012 |
Anti-Phospho-Bad [pS136] Polyclonal Antibody |
BAD is a 23 kDa member of the Bcl-2 family and acts to
promote apoptosis by forming
heterodimers with the survival proteins Bcl-2
and Bcl-xL, thus preventing them from binding with
BAX. BAD is found on the outer mitochondrial membrane and, once
phosphorylated in response
to stimulation growth stimuli, translocates to the cytoplasm. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-1018 |
Anti-Phospho-Bcl-xL [pS62] Polyclonal Antibody |
Bcl-xL is a ~28 kDa member of Bcl-2 family of proteins and
an important regulator of apoptosis. Bcl-xL forms
heterodimers with BAX, BAK, and Bcl-2, and its overexpression in tumor cells
confers resistance against chemotherapeutic drugs. Bcl-xL is phosphorylated
on many sites including serine 62, a critical site for Bcl-xL response to
microtubule-damaging drugs such as taxol and vinblastine. Phosphorylation of
serine 62 – thought to be mediated by Jun N-terminal stress kinase (JNK)
signaling – negatively regulates the anti-apoptotic function of Bcl-xL and
controls the growth of neoplastic cells. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-1019 |
Anti-Phospho-BimEL [pS69] (Human) / [pS65] Rat Polyclonal Antibody |
Bim (bcl-2-interacting mediator of cell death) is a
proapoptotic member of the Bcl-2 family that
shares only the BH3 domain with this family.
There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in
regulating the intrinsic mitochondrial apoptotic pathway by inducing
cytochrome c release, which in turn, activates caspase-9 and then caspase-3. |
polyclonal |
rabbit IgG, affinity-purified |
10 blot |
WB |
| AT-1021 |
Anti-Phospho-PED/PEA-15 [pS116] Polyclonal Antibody |
PED/PEA-15 (Phosphoprotein Enriched in
Diabetes/Phosphoprotein Enriched in Astrocytes - 15 kDa) is a widely expressed 15 kDa protein comprised of an
N-terminal region containing a canonical Death Effector Domain (DED) sequence
and a nuclear export signal, and a C-terminal region containing two serine
phosphorylation sites. PED/PEA-15 has been implicated in the regulation of
multiple cellular processes including apoptosis, integrin activation, and
insulin-sensitive glucose transport in insulin-responsive cells.
Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116
(a substrate of CaMKII and Akt) is required for PED/PEA-15 function. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| Cell surface |
| AT-2041 |
Anti-IGF-1R (beta-Subunit) Monoclonal Antibody |
Insulin-like growth factor-1 receptor (IGF-1R, also known
as CD221), a member of the
tyrosine kinase superfamily, is a broadly
expressed transmembrane receptor that plays a
key role in supporting cell growth and differentiation, and imparts
resistance to
apoptosis. |
194Q13 |
Mouse IgG2b k |
100 µg |
WB |
| AT-2004 |
Anti-Phospho-Insulin Receptor (IR) [pY972] Polyclonal
Antibody |
Biological actions of insulin are mediated by the insulin
receptor (IR), a receptor tyrosine kinase that
regulates multiple signaling pathways through activation of a series of
phosphorylation cascades. The IR is a heterotetrameric protein consisting of
two ligand-binding a subunits and two beta subunits that each contain a
tyrosine kinase domain. Tyrosine 972 is in the juxtamembrane Asn-Pro-Glu-Tyr
(NPEY) motif. Phosphorylation of IR tyrosine 972 is required for the binding
and/or phosphorylation of the adapter protein Shc, the PTB domain, IRS-1, PI3
kinase, and the Suppressor of Cytokine Signaling (SOCS). |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-2002 |
Anti-Phospho-Integrin alpha4 [pS988] Polyclonal Antibody |
Integrin alpha4 (also called CD49d) is a ~150 kDa protein
that possesses a large extracellular domain
involved in ligand binding, a single transmembrane domain, and an
intracellular regulatory domain possessing multiple sites for
phosphorylation. The presence of integrin alpha4 promotes cell migration and
inhibits cell spreading and contractility. Phosphorylation of the serine 988
residue on the integrin alpha4 cytoplasmic tail inhibits its interaction with
the focal adhesion complex-associated protein paxillin, and modulates its
effects on cell motility and spreading. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB, IP |
| AT-2005 |
Anti-Phospho-Integrin beta1 [pS785] Polyclonal Antibody |
Integrin beta1, also known as CD29, is a 130 kDa
transmembrane glycoprotein that forms non-covalent
complexes with various Integrin alpha subunits to form the functional
receptors that bind to specific extracellular matrix proteins. Interactions
between integrins and the extracellular matrix lead to activation of signal
transduction pathways and regulation of gene expression. Phosphorylation of
serine 785 on the Integrin beta1 promotes cell attachment, but inhibits
spreading and migration, whereas dephosphorylation promotes cell spreading
and migration. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-2006 |
Anti-Phospho-Integrin beta3 [pY773] Polyclonal Antibody |
Integrin beta3, also known as CD61, is a 130 kDa
transmembrane glycoprotein that binds noncovalently
in complexes with integrin alpha subunits (alphaIIb, alphav) to form the
functional receptor that binds
to specific extracellular matrix proteins (e.g., fibronectin, vitronectin,
etc.). Integrin receptors are
involved in the regulation of a variety of important biological functions,
including embryonic
development, wound repair, hemostasis, and prevention of programmed cell
death. |
polyclonal |
rabbit IgG, affinity purified |
100 µL |
WB |
| AT-2003 |
Anti-Phospho-Integrin beta3 [pY785] Polyclonal Antibody |
Integrin beta3, also known as CD61, is a 130 kDa
transmembrane glycoprotein that binds non-covalently
in complexes with integrin alpha subunits (alphaIIb, alphav) to form the
functional receptor that binds to specific extracellular matrix proteins
(e.g., fibronectin, vitronectin, etc.).
The clustering of integrin receptors on the cell surface and their
binding to the extracellular matrix leads to the formation of focal contacts
and the activation of various signal transduction pathways. Phosphorylation of tyrosine 785 on Integrin
beta3 is essential for Shc and Grb2 binding, and promotes cell
migration. Tyr785 is commonly referred
to as Tyr759, the corresponding site in the chicken Integrin beta3 protein. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2001 |
Anti-TIMP-1 Monoclonal, Biotin Conjugated |
Recognizes natural and recombinant human TIMP-1. |
RRUT3 |
Mouse IgG1, Biotin Conj. |
0.1 mg |
ELISA |
| AT-2012 |
Anti-CD40 Monoclonal Antibody |
CD40 is expressed on peripheral blood and tonsillar
B-cells, most B-cell lymphomas and leukemias, as
well as several pre-B-cell leukemias and some carcinomas. EA-5
immunoprecipitates proteins of 48 and 45 kDa. |
EA-5 |
Mouse IgG1, Azide Free |
100 µg |
FC, IP, BS |
| AT-2008 |
Anti-CXCR1 Monoclonal Antibody |
CXCR1 and CXCR2, previously known as IL-8RA, or type I
IL-8 receptor, and IL-8RB, or type II IL-8 receptor,
respectively, have been shown to share approximately 77% amino acid sequence
identity. |
501 |
Mouse IgG1 |
0.5 mg |
FC, WB, ELISA, IHC, CS |
| AT-2009 |
Anti-CXCR1 Monoclonal Antibody |
CXCR1 and CXCR2, previously known as IL-8RA, or type I
IL-8 receptor, and IL-8RB, or type II IL-8 receptor,
respectively, have been shown to share approximately 77% amino acid sequence
identity. |
501 |
Mouse IgG1 |
0.1 mg |
FC, WB, ELISA, IHC, CS |
| AT-2010 |
Anti-CXCR2 Monoclonal Antibody |
CXCR1 and CXCR2, previously known as IL-8RA, or type I
IL-8 receptor, and IL-8RB, or type II IL-8 receptor,
respectively, have been shown to share approximately 77% amino acid sequence
identity. |
19 |
Mouse IgG1 |
0.5 mg |
FC, WB, ELISA, IHC, CS |
| AT-2011 |
Anti-CXCR2 Monoclonal Antibody |
CXCR1 and CXCR2, previously known as IL-8RA, or type I
IL-8 receptor, and IL-8RB, or type II IL-8 receptor,
respectively, have been shown to share approximately 77% amino acid sequence
identity. |
19 |
Mouse IgG1 |
0.1 mg |
FC, WB, ELISA, IHC, CS |
| AT-2007 |
Anti-CXCR4 Monoclonal Antibody |
The 12G5 mAb reacts with the chemokine receptor CXCR4,
previously called Fusin or LESTER. |
12G5 |
Mouse IgG2a, κ |
0.5 mg |
FC, IHC, CS |
| AT-2013 |
Anti-Phospho-c-Kit [pY703] Polyclonal Antibody |
c-Kit, also known as CD117 and stem cell factor receptor,
is a 145 kDa transmembrane tyrosine kinase encoded
by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological
responses including cell proliferation, apoptosis, chemotaxis and adhesion.
Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and
activation of the Ras --> Raf --> ERK1&2 signaling pathway. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2014 |
Anti-Phospho-c-Kit [pY721] Polyclonal Antibody |
c-Kit, also known as CD117 and stem cell factor receptor,
is a 145 kDa transmembrane tyrosine
kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a
variety of biological responses
including cell proliferation, apoptosis, chemotaxis and adhesion. |
polyclonal |
rabbit IgG, affinity purified |
100 µL |
WB |
| AT-2015 |
Anti-Phospho-c-Kit [pY730] Polyclonal Antibody |
c-Kit, also known as CD117 and stem cell factor receptor,
is a 145 kDa transmembrane tyrosine
kinase encoded by the c-Kit proto-oncogene. c-Kit regulates a variety of
biological responses
including cell proliferation, apoptosis, chemotaxis and adhesion. |
Polyclonal |
rabbit IgG |
100 µL |
WB |
| AT-2016 |
Anti-Phospho-c-Kit [pY936] Polyclonal Antibody |
c-Kit, also known as CD117 and stem cell factor receptor,
is a 145 kDa transmembrane tyrosine kinase encoded
by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological
responses including cell proliferation, apoptosis, chemotaxis and adhesion.
Phosphorylation at tyrosine 936 of c-Kit allows binding of Grb2 and
activation of the Ras --> Raf --> ERK1&2 signaling pathway. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2017 |
Anti-beta-Catenin Monoclonal Antibody |
This antibody binds to
beta-catenin, a protein with Mr=92 kDa. The catenins (alpha, beta, and gamma)
are ubiquitously expressed cytoplasmic proteins that associate with
E-cadherin to mediate Ca2+ dependent cell-cell adhesion, a process which is regulated
by phoshorylation of the protein tyrosine residues. |
428Q14 |
Mouse IgG1κ |
100 µg |
WB |
| AT-2034 |
Anti-Phospho-beta-Catenin [pS45] Polyclonal Antibody |
beta-catenin (92 kDa) is a multifunctional protein
involved in cell-cell adhesion, intracellular signalin>g, and gene transcription. beta-catenin plays a key role in the Wnt
pathway which mediates numerous developmental processes. Stabilizing
mutations of several serine/threonine residues (more frequently of serine 45)
have been found in multiple tumors. Phosphorylation of beta-catenin on serine
45 by casein kinase I (CKI) primes its subsequent phosphorylation of residues
33, 37, and 41 by glycogen synthase-3beta (GSK-3beta), and results in its
degradation. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2031 |
Anti-Phospho-FGFR1 [pYpY653/654] Polyclonal Antibody |
Fibroblast growth factor receptor 1 (FGFR1) is a member of
the fibroblast growth factor tyrosine
kinase receptor family (FGFR1, FGFR2, FGFR3, and FGFR4) and plays diverse
roles in various
developmental and physiological processes. |
polyclonal |
rabbit IgG, affinity chromatography |
10 blot |
WB, IF |
| AT-2037 |
Anti-Phospho-IR/IGF1R [pY1158] Polyclonal Antibody |
Tyrosine 1158 within the activation loop of the receptor
is an autophosphorylation site.
Together with tyrosines 1162 and 1163, it
is required to be phosphorylated for receptor activity. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB, IHC |
| AT-2038 |
Anti-Phospho-IR/IGF1R [pYpY1162/1163] Polyclonal Antibody |
Tyrosines 1162 and 1163 within the activation loop of the
receptor are autophosphorylation sites. Together
with tyrosine 1158, they are required to be phosphorylated for receptor
activity. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB, IHC |
| AT-2039 |
Anti-Phospho-IR/IGF1R [pYpYpY1158/1162/1163] Polyclonal Antibody |
The catalytic loops within the tyrosine kinase domains of
the IR/IGF1R contain a three tyrosine motif
corresponding to Tyr 1158, 1162 and 1163 (for the IR) and Tyr 1131, 1135 and
1136 (for the IGF1R). |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-2026 |
Anti-Phospho-Paxillin [pS126] Polyclonal Antibody |
Paxillin is a 68 kDa cytoskeletal adapter protein involved
in organization and function of focal adhesions,
which are critical to cell adhesion and migration. These cellular events in
turn play a role in a wide variety of processes including embryogenesis,
organogenesis, wound repair, inflammation and cancer. Serine 126 of paxillin
is phosphorylated as a result of Raf stimulation, through the Raf --> MEK
--> ERK pathway. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2027 |
Anti-Phospho-Paxillin [pS178] Polyclonal Antibody |
Paxillin is a 68 kDa cytoskeletal adapter protein involved
in organization and function of focal adhesions,
which are critical to cell adhesion and migration. Cell adhesion and
migration turn play a role in a wide variety of processes including
embryogenesis, organogenesis, wound repair,
inflammation and cancer. Serine 178 of paxillin is phosphorylated by cdc2
kinase during mitosis. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2036 |
Anti-Phospho-Paxillin [pY118] Polyclonal Antibody |
Paxillin is a 68 kDa cytoskeletal adapter protein involved
in organization and function of focal
adhesions, which are critical to cell adhesion
and migration. This in turn plays a role in a wide
variety of processes including embryogenesis, organogenesis, wound repair,
inflammation and
cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding
domains that serve as
docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk2,
Src), serine/threonine
kinases, GTPase activating proteins and other adaptor proteins (e.g.,
actin, vinculin, Crk). |
polyclonal |
rabbit IgG, affinity-purified |
100 µL |
WB, Immunostaining. |
| AT-2035 |
Anti-Phospho-Paxillin [pY31] Polyclonal Antibody |
Paxillin is a 68 kDa cytoskeletal adapter protein involved
in organization and function of focal adhesions,
which are critical to cell adhesion and migration. This in turn plays a role
in a wide variety of processes including embryogenesis, organogenesis, wound
repair, inflammation and cancer. Tyrosine 31, a Crk binding site of paxillin,
is phosphorylated during integrin-mediated cell adhesion. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB, IHC |
| AT-2019 |
Anti-Phospho-PDGFRalpha [pY742] Polyclonal Antibody |
Platelet-derived growth factor receptor (PDGFR) is a
transmembrane glycoprotein of 170-185 kDa which
undergoes homo- or heterodimerization into complexes of alpha and beta
subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB
or -AB) that binds. The phosphorylation of tyrosine residues in the
ligand-activated receptor can control multiple signaling events such as actin
reorganization, transcription, cell growth, migration and differentiation,
and also lead to activation of the Ras --> Raf --> ERK1&2 pathway.
Tyrosine 742 in PDGFRalpha is a binding site for PI3-kinase. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2020 |
Anti-Phospho-PDGFRalpha [pY754] Polyclonal Antibody |
Platelet-derived growth factor receptor (PDGFR) is a
transmembrane glycoprotein of 170-185 kDa which
undergoes homo- or heterodimerization into complexes of alpha and beta
subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB
or -AB) that binds. The phosphorylation of tyrosine residues in the now
activated receptor can control multiple signaling events such as actin
reorganization, transcription, cell growth, migration and differentiation,
and also lead to activation of the Ras --> Raf --> ERK1&2 pathway.
Phosphorylation of tyrosine 754 in the alpha subunit of the heterodimeric
complex is thought to initiate specific signal-transduction pathways distinct
from those initiated via homodimeric receptor complexes, as tyrosine 754 has
not been shown to be phosphorylated in those complexes. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2021 |
Anti-Phospho-PDGFRalpha [pY762] Polyclonal Antibody |
Platelet-derived growth factor receptor (PDGFR) is a
transmembrane glycoprotein of 170-185 kDa which
undergoes homo- or heterodimerization into complexes of alpha and beta
subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB
or -AB) that binds. The phosphorylation of tyrosine residues in the now
activated receptor can control multiple signaling events such as actin
reorganization, transcription, cell growth, migration and differentiation,
and also lead to activation of the Ras --> Raf --> ERK1&2 pathway.
PDGFRalpha tyrosine 762 is autophosphorylated in the activated receptor, and
serves as a binding site for Crk proteins. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2025 |
Anti-Phospho-PDGFRalpha [pY849] / beta [pY857] Polyclonal Antibody |
Platelet-derived growth factor receptor (PDGFR) is a
transmembrane glycoprotein of 170-185 kDa
which undergoes homo- or heterodimerization into complexes of alpha and
beta subunits upon ligand
binding, depending on the isoform of PDGF (PDGF-AA, -BB or -AB) that binds. |
polyclonal |
rabbit IgG, affinity-purified |
100 µL |
WB |
| AT-2018 |
Anti-Phospho-PDGFRalpha [pYpY572/574] / beta [pYpY579/581] Polyclonal Antibody |
Platelet-derived growth factor receptor (PDGFR) is a
transmembrane glycoprotein of 170-185 kDa which
undergoes homo- or heterodimerization into complexes of alpha and beta
subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB
or -AB) that binds. The phosphorylation of tyrosine residues in the now
activated receptor can control multiple signaling events such as actin
reorganization, transcription, cell growth, migration and differentiation.
PDGFRalpha tyrosines 572 and 574 (579 and 581 in PDGFRbeta) are
autophosphorylated in the activated receptor, and bind and activate Src family
kinases. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2032 |
Anti-Phospho-VE-cadherin [pY658] Polyclonal Antibody |
VE-cadherin (cadherin-5) is an endothelial specific
adhesion molecule that is essential for the
maintenance of endothelial barrier function and
angiogenesis. VE-cadherin is linked to the actin
cytoskeleton through a number of adaptor proteins including a-, beta-, and
gamma-catenin. Cytoskeletal
dynamics and phosphorylation regulate VE-cadherin mediated cell-cell
adhesion. |
Polyclonal |
rabbit IgG |
10 blot |
WB |
| AT-2033 |
Anti-Phospho-VE-cadherin [pY731] Polyclonal Antibody |
VE-cadherin (cadherin-5) is an endothelial specific
adhesion molecule that is essential for the
maintenance of endothelial barrier function and
angiogenesis. VE-cadherin is linked to the actin
cytoskeleton through a number of adaptor proteins including alpha-, beta-,
and gamma-catenin. Cytoskeletal
dynamics and phosphorylation regulate VE-cadherin mediated cell-cell
adhesion. |
Polyclonal |
rabbit IgG |
10 blot |
WB |
| AT-2023 |
Anti-Phospho-VEGFR2 [pY1054] Polyclonal Antibody |
Vascular endothelial growth factor receptor 2 (VEGFR2,
also known as KDR/FLK-1) is a 200 kDa member of a
receptor tyrosine kinase family whose activation plays an essential role in a
large number of biological processes such as embryonic development, wound
healing, cell proliferation, migration and differentiation. Phosphorylation
of tyrosines 1054 and 1059 in the activation loop is required for activation
of VEGFR2 and its intrinsic tyrosine kinase activity. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2024 |
Anti-Phospho-VEGFR2 [pY1214] Polyclonal Antibody |
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2,
also known as KDR/FLK-1) is a ~200 kDa member of a
receptor tyrosine kinase family whose activation plays an essential role in a
large number of biological processes such as embryonic development, wound
healing, cell proliferation, migration, and differentiation. Phosphorylation
of tyrosine 1214 is reported to play a critical role in regulation of
receptor autophosphorylation and stimulation of intrinsic tyrosine kinase
catalytic activity. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2022 |
Anti-Phospho-VEGFR2 [pY951] Polyclonal Antibody |
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2,
also known as KDR/FLK-1) is a ~200 kDa member of a
receptor tyrosine kinase family whose activation plays an essential role in a
large number of biological processes such as embryonic development, wound
healing, cell proliferation, migration, and differentiation. Phosphorylation
of tyrosine 951 in the kinase insert domain of VEGFR2 regulates vascular
permeability factor/VEGF-induced endothelial cell migration. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-2040 |
Anti-Phospho-VEGFR2 [pYpY1054/1059] Polyclonal Antibody |
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2,
also known as KDR/FLK-1) is a ~200 kDa member of a
receptor tyrosine kinase family whose activation plays an essential role in a
large number of biological processes such as embryonic development, wound
healing, cell
proliferation, migration, and differentiation. |
Polyclonal |
rabbit IgG |
100 µL |
WB |
| AT-2028 |
Anti-Phospho-Vinculin [pY100] Polyclonal Antibody |
Vinculin is an ubiquitously expressed cytoskeletal protein
(~130 kDa) involved in cell adhesion and cell
migration. The vinculin protein consists of a globular head domain connected
to an elongated tail region by a proline-rich domain. The head region
contains binding sites for two cytoskeletal proteins, alpha-actinin and
talin, as well as a binding site for the tail region of vinculin itself. The
tail region contains binding sites for actin, the cytoskeletal protein,
paxillin, and PI(4,5)P2. |
polyclonal |
rabbit IgG, affinity-purified |
10 blot |
WB |
| AT-2029 |
Anti-Phospho-Vinculin [pY1065] Polyclonal Antibody |
Vinculin is an ubiquitously expressed cytoskeletal protein
(~130 kDa) involved in cell adhesion and cell
migration. The vinculin protein consists of a globular head domain connected
to an elongated tail region by a proline-rich domain. The head region
contains binding sites for two
cytoskeletal proteins, alpha-actinin and talin, as well as a binding site
for the tail region of vinculin itself. The tail region contains binding
sites for actin, the cytoskeletal
protein, paxillin, and PI(4,5)P2. |
polyclonal |
rabbit IgG, affinity purified |
10 blot |
WB |
| AT-2030 |
Anti-Phospho-Vinculin [pY822] Polyclonal Antibody |
Vinculin is an ubiquitously expressed cytoskeletal protein
(~130 kDa) involved in cell adhesion and cell
migration. Data indicate the possible involvement of phosphorylation of
tyrosine 822 of vinculin with the integrity/strength of integrin-mediated
focal adhesions. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| Cytokine |
| AT-3002 |
Anti-µ-Opioid Receptor pan Polyclonal Antibody |
Most actions of exogenous opioids, such as morphine, are
mediated through the µ-opioid receptor,
including analgesia, tolerance and reward. In
general, opioids modulate numerous central and
peripheral processes including pain perception, neuroendocrine secretion
and the immune response. |
Polyclonal |
rabbit IgG, Azide Free |
100 µL |
WB |
| AT-3023 |
Anti-EGF Monoclonal, Biotin Conjugated |
Recognizes natural and recombinant human EGF. |
S-146 |
Mouse IgG1, Biotin Conj. |
0.2 mL |
ELISA |
| AT-3022 |
Anti-EGF Polyclonal Antibody |
Recognizes natural and recombinant human EGF. |
Polyclonal |
rabbit IgG |
0.5 mg |
ELISA |
| AT-3015 |
Anti-EMAP-II Polyclonal Antibody |
This antibody recognizes natural and recombinant human
EMAP-II. |
Polyclonal |
rabbit IgG |
0.1 mg |
ELISA, IHC, WB |
| AT-3017 |
Anti-G-CSF Monoclonal Antibody |
This antibody recognizes natural and recombinant human
G-CSF. |
BVD13-3A5 |
Rat IgG1, κ |
0.5 mg |
ELISA, WB |
| AT-3016 |
Anti-GM-CSF Monoclonal Antibody |
This antibody recognizes natural and recombinant human
GM-CSF. 127 AA (14 kDa) monomeric protein with two
glycosylation sites. Glycosylation is not required for activity, but the
glycosylated form is more active in vivo. |
BVD2-23B6 |
Rat IgG. 2a, κ, Azide Free |
0.5 mg |
NE, IP, FC, Immunoassay |
| AT-3041 |
Anti-GM-CSF Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
GM-CSF. 127 AA (14 kDa) monomeric protein with two
glycosylation sites. Glycosylation is not required for activity, but the
glycosylated form is more active in vivo. |
MP1-22E9 |
Rat IgG2a, κ |
0.5 mg |
ELISA |
| AT-3019 |
Anti-IFN-gamma Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IFN-gamma. 146 AA (~17 kDa) dimeric protein that
contains two cysteines that are not involved in disulfide bonding.
Glycosylation is not required for biological activity. |
MD-1 |
Mouse IgG1, κ |
0.5 mg |
IHC, ELISA, FC, IF |
| AT-3074 |
Anti-IFN-gamma Monoclonal Antibody |
This antibody recognizes natural and recombinant swine
IFN-gamma. 146 AA (~17 kDa) dimeric protein that
contains two cysteines that are not involved in disulfide bonding.
Glycosylation is not required for biological activity. |
A151D5B8 |
Mouse IgG1 |
0.5 mg |
ELISA |
| AT-3073 |
Anti-IFN-gamma Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant swine
IFN-gamma. 146 AA (~17 kDa) dimeric protein that
contains two cysteines that are not involved in disulfide bonding.
Glycosylation is not required for biological activity. |
A151D13C5 |
Mouse IgG1, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3047 |
Anti-IFN-gamma Polyclonal Antibody |
This antibody recognizes natural and recombinant mouse
IFN-gamma. 146 AA (~17 kDa) dimeric protein that
contains two cysteines that are not involved in disulfide bonding.
Glycosylation is not required for biological activity. |
Polyclonal |
rabbit IgG |
0.5 mg |
ELISA |
| AT-3072 |
Anti-IFN-gamma Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IFN-gamma. 146 AA (~17 kDa) dimeric protein that
contains two cysteines that are not involved in disulfide bonding.
Glycosylation is not required for biological activity. |
Polyclonal |
rabbit IgG |
0.5 mg |
WB, DB |
| AT-3003 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES3-9D7 |
Rat IgG1, κ, Azide Free |
0.5 mg |
NE, ELISA, FC |
| AT-3004 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES3-9D7 |
Rat IgG1, κ, Azide Free |
1.0 mg |
NE, ELISA, FC |
| AT-3048 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES5-SXC1 |
Rat IgM, Azide Free |
0.5 mg |
ELISA |
| AT-3064 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant rat
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
2G101H7 |
Mouse IgG1, Azide Free |
0.5 mg |
WB, DB, FC |
| AT-3030 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES5-2A5 |
Rat IgG1, κ |
0.5 mg |
ELISA, NE |
| AT-3049 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES5-SXC1 |
Rat IgM |
0.5 mg |
ELISA |
| AT-3070 |
Anti-IL-10 Monoclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
945A4C437B1 |
Mouse IgG1 |
0.5 mg |
ELISA |
| AT-3031 |
Anti-IL-10 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
JES5-2A5 |
Rat IgG1, κ, Biotin Conj. |
0.1 mg |
ELISA, NE |
| AT-3075 |
Anti-IL-10 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant swine
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
945A1A926C2 |
Mouse IgG1, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3053 |
Anti-IL-10 Polyclonal Antibody |
This antibody recognizes natural and recombinant rat
IL-10. 160 AA homodimeric protein with 2 disulfide
bonds per monomer. IL-10 is secreted from activated CD8 positive T cells,
B-cell lymphomas, LPS activated monocytes and mast cells. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB, ELISA, DB, IHC |
| AT-3006 |
Anti-IL-13 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-13. 111 AA (~12 kDa) protein with 2 disulfide
bonds that are critical for biological activity. IL-13 is mainly produced by
activated Th2 cells. |
JES10-5A2 |
Rat IgG1, κ, Azide Free |
0.5 mg |
NE, ELISA, WB, IHC, FC |
| AT-3054 |
Anti-IL-13 Monoclonal Antibody |
This antibody recognizes natural and recombinant rat
IL-13. 111 AA (~12 kDa) protein with 2 disulfide
bonds that are critical for biological activity. IL-13 is mainly produced by
activated Th2 cells. |
A13D12G5 |
Mouse IgG1., Azide Free |
0.5 mg |
FC, WB, DB, ELISA |
| AT-3021 |
Anti-IL-13 Polyclonal, Biotin Conjugated |
Recognizes natural and recombinant human IL-13. 111 AA
(~12 kDa) protein with 2 disulfide bonds that are
critical for biological activity. IL-13 is mainly produced by activated Th2
cells. |
Polyclonal |
rabbit IgG, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3007 |
Anti-IL-15 Polyclonal Antibody |
This antibody recognizes natural and recombinant human
IL-15. 114 AA (~13 kDa) protein with disulfide
bonds that are critical for activity. IL-15 is glycosylated but this is not
required for biological activity. T-cells are a major source of IL-15. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
ELISA, WB, NE |
| AT-3008 |
Anti-IL-15 Polyclonal Antibody |
This antibody recognizes natural and recombinant human
IL-15. 114 AA (~13 kDa) protein with disulfide
bonds that are critical for activity. IL-15 is glycosylated but this is not
required for biological activity. T-cells are a major source of IL-15. |
Polyclonal |
rabbit IgG |
0.5 mg |
ELISA, WB, NEU |
| AT-3009 |
Anti-IL-15 Polyclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant human
IL-15. 114 AA (~13 kDa) protein with disulfide
bonds that are critical for activity. IL-15 is glycosylated but this is not
required for biological activity. T-cells are a major source of IL-15. |
Polyclonal |
rabbit IgG, Biotin Conj. |
0.1 mg |
ELISA, WB, NE |
| AT-3065 |
Anti-IL-1alpha Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-1 alpha. either a 269 AA or a 271 AA (17 kDa)
protein with no disulfide bonds. There are two distinct molecular forms of
IL-1 (IL-1alpha and IL-1beta) derived from two different genes. |
Polyclonal |
rabbit IgG |
0.5 mg |
WB |
| AT-3037 |
Anti-IL-1ß Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-1 beta. either a 269 AA or a 271 AA (17 kDa)
protein with no disulfide bonds. There are two distinct molecular forms of
IL-1 (IL-1alpha and IL-1beta) derived from two different genes. |
13A10 |
Rat IgG1 |
0.5 mg |
ELISA |
| AT-3033 |
Anti-IL-1ß Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-1 beta. either a 269 AA or a 271 AA (17 kDa)
protein with no disulfide bonds. There are two distinct molecular forms of
IL-1 (IL-1alpha and IL-1beta) derived from two different genes. |
13D11 |
Rat IgG1, Biotin Conj. |
0.1 mg |
ELISA, IHC |
| AT-3057 |
Anti-IL-1ß Polyclonal Antibody |
This antibody recognizes natural and recombinant rat IL-1
beta. either a 269 AA or a 271 AA (17 kDa) protein
with no disulfide bonds. There are two distinct molecular forms of IL-1
(IL-1alpha and IL-1beta) derived from two different genes. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
ELISA, WB, DB |
| AT-3071 |
Anti-IL-1ß Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-1 beta. either a 269 AA or a 271 AA (17 kDa)
protein with no disulfide bonds. There are two distinct molecular forms of
IL-1 (IL-1alpha and IL-1beta) derived from two different genes. |
Polyclonal |
rabbit IgG |
0.5 mg |
WB |
| AT-3025 |
Anti-IL-2 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-2. 133 AA (15 kDa) protein with a single
disulfide bond that is critical for activity. IL-2 is glycosylated but this
is not required for biological activity. |
JES6-5H4 |
Rat IgG2b, κ , Azide Free |
0.5 mg |
ELISA, IP, FC |
| AT-3034 |
Anti-IL-2 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-2. 133 AA (15 kDa) protein with a single
disulfide bond that is critical for activity. IL-2 is glycosylated but this
is not required for biological activity. |
JES6-1A12 |
Rat IgG2a, κ |
0.5 mg |
ELISA, IP |
| AT-3058 |
Anti-IL-2 Monoclonal Antibody |
This antibody recognizes natural and recombinant rat IL-2.
133 AA (15 kDa) protein with a single disulfide
bond that is critical for activity. IL-2 is glycosylated but this is not
required for biological activity. |
7H11AB7 |
Mouse IgG1 |
0.5 mg |
FC, WB, IP |
| AT-3026 |
Anti-IL-2 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-2. 133 AA (15 kDa) protein with a single
disulfide bond that is critical for activity. IL-2 is glycosylated but this
is not required for biological activity. |
JES6-5H4 |
Rat IgG2b, κ , Biotin Conj. |
0.1 mg |
ELISA, IP, FC, IHC |
| AT-3056 |
Anti-IL-2 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant at
IL-2. 133 AA (15 kDa) protein with a
single disulfide bond that is critical for
activity. IL-2 is glycosylated but this is not required for biological
activity. |
12B11AE7 |
Mouse IgG1, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3051 |
Anti-IL-2 Polyclonal Antibody |
This antibody recognizes natural and recombinant rat IL-2.
133 AA (15 kDa) protein with a single disulfide
bond that is critical for activity. IL-2 is glycosylated but this is not
required for biological activity. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB, ELISA, DB |
| AT-3066 |
Anti-IL-2 Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-2. 133 AA (15 kDa) protein with a single
disulfide bond that is critical for activity. IL-2 is glycosylated but this
is not required for biological activity. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB, DB |
| AT-3077 |
Anti-IL-2R (CD132) Monoclonal Antibody |
This monoclonal antibody recognizes the interleukin-2
(IL-2) receptor gamma chain (IL-2Rgamma), a cell
surface glycoprotein with Mr=64-70 kDa expressed by a variety of leukocytes
including T cells, B cells, NK cells, monocytes, macrophages, and neutrophi. |
gc1 |
Mouse IgG1 |
100 µg |
IP, FC, IHC |
| AT-3076 |
Anti-IL-2R/CD25 Monoclonal Antibody |
Recognizes an antigen of 55-60 kDa. |
143-13 |
Mouse IgG1, Azide Free |
0.1 mg |
FC, IF, IHC |
| AT-3027 |
Anti-IL-4 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
BVD4-1D11 |
Rat IgG2b, κ , Azide Free |
0.5 mg |
ELISA, BS, Neutralization, FC |
| AT-3028 |
Anti-IL-4 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
BVD4-1D11 |
Rat IgG2b, κ |
0.5 mg |
ELISA, BS, Neutralization, FC |
| AT-3059 |
Anti-IL-4 Monoclonal Antibody |
This antibody recognizes natural and recombinant rat IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
4C4AD2 |
Mouse IgG1 |
0.5 mg |
ELISA |
| AT-3038 |
Anti-IL-4 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
BVD6-24G2 |
Rat IgG1, κ, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3055 |
Anti-IL-4 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant rat IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
12F8BC8 |
Mouse IgG1, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3067 |
Anti-IL-4 Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-4.
129 AA (~20 kDa) protein with three disulfide
bonds that are critical for biological activity. IL-4 is glycosylated but
this is not required for biological activity. |
Polyclonal |
rabbit IgG |
0.5 mg |
WB, DB |
| AT-3012 |
Anti-IL-5 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-5.
113 AA for the murine protein and 115 AA for the
human. The biologically active form is a disulfide linked n-glycosylated
homodimer (glycosylation is not required for activity). |
JES1-39D10 |
Rat IgG2a, κ |
0.5 mg |
FC, ELISA |
| AT-3039 |
Anti-IL-5 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-5.
113 AA for the murine protein and 115 AA for the
human. The biologically active form is a disulfide linked n-glycosylated
homodimer (glycosylation is not required for activity). |
TRFK-4 |
Rat IgG2a, κ, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3010 |
Anti-IL-6 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-6. 185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
8H12 |
Mouse IgG1, Azide Free |
0.5 mg |
FC, ELISA, WB |
| AT-3035 |
Anti-IL-6 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-6. 185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
MP5-20F3 |
Rat IgG1, Azide Free |
0.5 mg |
ELISA, Neutralization, WB, FC,
IHC |
| AT-3036 |
Anti-IL-6 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-6.
185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
MP5-20F3 |
Rat IgG1 |
0.5 mg |
ELISA, Neutralization, WB, FC,
IHC |
| AT-3060 |
Anti-IL-6 Monoclonal Antibody |
This antibody recognizes natural and recombinant rat IL-6.
185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
10E5 |
Mouse IgG2b |
0.5 mg |
FC, WB, DB |
| AT-3040 |
Anti-IL-6 Monoclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant mouse
IL-6.
185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
MP5-32C11 |
Rat IgG2a, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3052 |
Anti-IL-6 Polyclonal Antibody |
This antibody recognizes natural and recombinant rat IL-6.
185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB, ELISA, DB |
| AT-3068 |
Anti-IL-6 Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-6. 185 AA protein with disulfide bonds that are
critical for activity. IL-6 is glycosylated but this is not required for
biological activity. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB |
| AT-3011 |
Anti-IL-7 Monoclonal Antibody |
This antibody recognizes natural and recombinant human
IL-7.
152 AA for the human protein and 129 AA for the
murine homologue. The disulfide bonds are required for biological activity. |
BVD10-40F6 |
Rat IgG1, κ |
0.5 mg |
ELISA, NE |
| AT-3069 |
Anti-IL-8/NAP-1 Polyclonal Antibody |
This antibody recognizes natural and recombinant swine
IL-8/NAP-1. 72 AA (8 kDa) non-glycosylated
protein. IL-8 has two disulfide bonds and is a member of the CXC chemokine
family. IL-8 is produced by stimulated monocytes. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
NE, WB |
| AT-3001 |
Anti-kappa-Opioid Receptor Polyclonal Antibody |
Activation of the kappa-opioid receptor opposes a variety
of µ-opioid receptor mediated actions throughout
the brain and spinal cord. In general, opioids modulate numerous central and
peripheral processes, including pain perception, neuroendocrine secretion and
the immune response. |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-3061 |
Anti-MIP-2 Polyclonal Antibody |
This antibody recognizes natural and recombinant rat
MIP-2. |
Polyclonal |
rabbit IgG |
0.5 mg |
ELISA |
| AT-3062 |
Anti-MIP-2 Polyclonal, Biotin Conjugated |
This antibody recognizes natural and recombinant rat
MIP-2. |
Polyclonal |
rabbit IgG, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3078 |
Anti-Phospho-Glycogen Synthase[pSpS641/645] Polyclonal Antibody |
Glycogen Synthase (GS), is an 85 kDa protein and a key
enzyme in regulating glycogen synthesis
by catalyzing the rate-limiting step of UDP-glucose incorporation into
glycogen. The activity of
glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines
and glucagons) and
non-hormonal stimuli (blood glucose level and exercise). |
polyclonal |
rabbit IgG, affinity-purified |
10 blot |
WB |
| AT-3013 |
Anti-RANTES Monoclonal Antibody |
This antibody recognizes natural and recombinant human
RANTES. |
VL1 |
Mouse IgG2b kappa |
0.5 mg |
ELISA, IHC, WB, IP, CS |
| AT-3014 |
Anti-RANTES Monoclonal, Biotin Conjugated |
ASR-Analyte Specific Reagent. This antibody recognizes
natural and recombinant human RANTES. |
VL1 |
Mouse IgG2b kappa, Biotin Conj. |
0.1 mg |
ELISA, IHC, WB, IP, CS |
| AT-3045 |
Anti-TNF-alpha Monoclonal Antibody |
This antibody recognizes both native and recombinant
TNF-alpha. |
MP6-XT3 |
rat IgG1, Azide-free |
0.5 mg |
NE, EA |
| AT-3063 |
Anti-TNF-alpha Polyclonal Antibody |
This antibody detects both natural and recombinant
TNF-alpha. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
WB, DB |
| AT-3042 |
Anti-TNF-alpha Polyclonal Antibody |
This antibody detects both natural and recombinant
TNF-alpha. |
Polyclonal |
rabbit IgG |
0.5 mg |
ELISA |
| AT-3043 |
Anti-TNF-alpha Polyclonal, Biotin Conjugated |
This antibody detects both natural and recombinant
TNF-alpha. |
Polyclonal |
rabbit IgG, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3024 |
Anti-VEGF Polyclonal, Biotin Conjugated |
Recognizes natural and recombinant human VEGF. |
Polyclonal |
rabbit IgG, Biotin Conj. |
0.1 mg |
ELISA |
| AT-3044 |
Hamster Anti-TNF-alpha Monoclonal, Biotin Conjugated |
This antibody detects both natural and recombinant
TNF-alpha. |
H lg |
Hamster IgG, Biotin Conj. |
0.025 mg |
ELISA, WB |
| AT-3029 |
Rat Anti-IL-5 Monoclonal Antibody |
This antibody recognizes natural and recombinant mouse
IL-5.
113 AA for the murine protein and 115 AA for the
human. The biologically active form is a disulfide linked n-glycosylated
homodimer (glycosylation is not required for activity). |
TRFK-5 |
Rat IgG1, κ |
0.5 mg |
ELISA |
| AT-3046 |
Rat Anti-TNF-alpha Monoclonal Antibody |
This antibody recognizes both native and recombinant
TNF-alpha. |
MP6-XT3 |
rat IgG1 |
0.5 mg |
NE, EA |
| AT-3018 |
Rat Anti-TNF-alpha Polyclonal Antibody |
Tumor necrosis factor-alpha is a potent paracrine and
endocrine mediator of inflammatory and immune
functions. TNF-alpha is secreted by activated monocytes and macrophages, and
many other cells including B cells, T cells and fibroblasts. |
Polyclonal |
rabbit IgG, Azide Free |
0.5 mg |
NE, WE, EA |
| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| GPCR |
| AT-4001 |
Anti-Phospho-beta-Arrestin-1 [pS412] Polyclonal Antibody |
beta-arrestin-1 is a member of a family of proteins widely
expressed but especially abundant in the central
nervous system. Serving as an adaptor or scaffold molecule, beta-arrestin-1
is essential for mitogenic signaling and mediates agonist-dependent
desensitization and internalization of G protein-coupled receptors (GPCRs,
e.g., beta2-adrenergic receptor). beta-arrestin-1 in the cytosol is
phosphorylated by ERK1&2 on serine 412 in a negative feedback mechanism
and binds to the phosphorylated receptors at the plasma membrane. Serine 412
is then dephosphorylated and the GPCRs are internalized, leading to
activation of the Ras --> Raf --> ERK1&2 signaling pathway. |
Polyclonal |
rabbit IgG, Affinity-Purified |
10 blot |
WB |
| EP-4003 |
Rabbit Anti-P2Y2 RECEPTOR (RAT) Polyclonal Antibody |
This antibody is specific for the rat P2Y2 receptor |
Polyclonal |
rabbit IgG |
100 UG |
WB, ELISA |
| EP-4002 |
Rabbit Anti-P2Y2 RECEPTOR Polyclonal Antibody |
This antibody is specific for the human P2Y2 receptor. |
Polyclonal |
rabbit IgG |
100 UG |
WB, ELISA |
| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| Neuroscience |
| AT-5010 |
Anti-Abeta43 Cleavage Site Specific Polyclonal Antibody |
Used to detect Abeta 43, any reactivity towards both full
length Abeta [1-40] and Abeta [1-42] protein has
been eliminated. |
Polyclonal |
rabbit IgG, Azide Free |
25 µg |
DB, RIA, EA |
| AT-5008 |
Anti-alpha-Synuclein Monoclonal Antibody |
This antibody recognizes the 19kDa protein,
alpha-Synuclein, which belongs to a family of small cy>toplasmic proteins expressed in neurons. |
Syn 211 |
Mouse IgG1 |
0.1 mg |
ELISA, IHC, WB |
| AT-5007 |
Anti-APP (pan) Polyclonal Antibody |
Amyloid Precursor Protein (APP) is an integral membrane
protein with a large ectodomain, a transmembrane
domain, and a short cytoplasmic tail. This antibody recognizes the immature
APP, a protein with Mr=95 kDa and also
the APP holoprotein, a posttranslationally modified protein with Mr=100-120
kDa. |
Polyclonal |
rabbit IgG |
100 µg |
WB, EA |
| AT-5006 |
Anti-BACE-1 Polyclonal Antibody |
Beta site APP cleaving enzyme (BACE1), also identified as
beta secretase, is an aspartyl protease. The
mature form of the enzyme is an N-glycosylated integral membrane protein with
Mr=70 kDa. BACE1 cleaves Amyloid Precursor Protein (APP), generating two
fragments, the APP N terminal fragment (APPs) with Mr=100 kDa and
a smaller C-terminal fragment with Mr=12 kDa (C99). |
Polyclonal |
rabbit IgG |
100 µL |
WB |
| AT-5002 |
Anti-beta-Amyloid (Abeta) (N-terminal) Polyclonal Antibody |
This antibody recognizes the N-terminal region of Abeta,
which is the beta-secretase splice site of APP. No
cross reactivity against negative spanning regions of Abeta have been
observed by ELISA. |
Polyclonal |
rabbit IgG |
50 µg |
DB, RIA, EA |
| AT-5003 |
Anti-beta-Amyloid (Abeta) (N-terminal) Polyclonal Antibody |
This antibody recognizes the N-terminal region of Abeta,
which is the beta-secretase splice site of APP. No
cross reactivity against negative spanning regions of Abeta have been
observed by ELISA. |
Polyclonal |
rabbit IgG |
100 µg |
DB, RIA, EA |
| AT-5001 |
Anti-beta-Amyloid (Abeta) (pan) Polyclonal Antibody |
This antibody recognizes the sequence of Abeta [1-40] in
the region from amino acids 15-30. No blocking
activity was observed with Abeta [1-12] whereas the peptides Abeta [14-35],
Abeta [15-28] and Abeta [17-30] were all able to block antibody activity as
well as Abeta [1-40]. |
Polyclonal |
rabbit IgG, Azide Free |
100 µg |
IHC, DB, RIA, EA |
| AT-5011 |
Anti-beta-Amyloid 42 Cleavage Site Specific Polyclonal
Antibody |
Used to detect Abeta 42, any reactivity towards both full
length Abeta [1-40] and Abeta [1-43] protein has
been eliminated. |
Polyclonal |
rabbit IgG, Azide Free |
25 µg |
DB, RIA, EA, IHC |
| AT-5009 |
Anti-Mouse Abeta Monoclonal Antibody |
Alzheimer’s Disease (AD) is characterized by the presence
of extracellular plaques and
intracellular neurofibrillary tangles (NFTs) in
the brain. The major component of these
plaques is Abeta peptide (beta-amyloid), a 40 to 43 amino acid peptide
cleaved from amyloid
precursor protein (APP). Increased release of the ‘longer forms’ of Abeta
peptide, Abeta42 or
Abeta43, which have a greater tendency to aggregate than Abeta40, occurs in
individuals
expressing certain genetic mutations, expressing certain ApoE alleles, or
may involve
other, still undiscovered, factors. |
252Q6 |
Mouse IgG1 κ , affinity chromatography |
100 µg |
ELISA, WB |
| AT-5014 |
Anti-Phospho-APP [pT668] Polyclonal Antibody |
Amyloid beta (A4) Precursor Protein (APP) is a
ubiquitously expressed transmembrane protein that
is
sequentially cleaved by beta-secretase and gamma-secretase to release
extracellular peptides such as the
beta-amyloid peptides, which are deposited in the brain in Alzheimer's
disease. |
polyclonal |
rabbit IgG, affinity chromatography |
2 blot |
WB |
| AT-5029 |
Anti-Phospho-Dab1 [pS491] Polyclonal Antibody |
Disabled 1 (Dab1) is an 80 kDa protein that is encoded by
the Disabled-1 gene locus which is mutated in
scrambler and yotari mutant mice. Dab1 is an intracellular adapter protein
that functions in downstream signaling events initiated by the secreted
protein reelin. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner
and regulates, likely indirectly, Reelin-induced signaling during neural
cortex development. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-5028 |
Anti-Phospho-Dab1 [pY198] Polyclonal Antibody |
Disabled 1 (Dab1) is an 80 kDa protein that is encoded by
the Disabled-1 gene locus which is mutated in
scrambler and yotari mutant mice. Dab1 is an intracellular adapter protein
that functions in downstream signaling events initiated by the secreted
protein reelin. Dab1 tyrosine 198 is a major site for reelin-induced Src
family kinase-mediated phosphorylation in embryonic neurons. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5013 |
Anti-Phospho-Dab1 [pY220] Polyclonal Antibody |
Disabled 1 (Dab1) is an 80 kDa protein that is encoded by
the Disabled-1 gene locus which is mutated in
scrambler and yotari mutant mice. Dab1 is an intracellular adapter protein
that functions in downstream signaling events initiated by the secreted
protein reelin. Dab1 tyrosine 220 is a major site for reelin-induced Src
family kinase-mediated phosphorylation in embryonic neurons. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-5015 |
Anti-Phospho-Tau [pS199] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons that functions to promote
tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB, IHC, EA |
| AT-5018 |
Anti-Phospho-Tau [pS214] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serine 214 is phosphorylated by GSK-3beta and cdk5 in AD brain. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5020 |
Anti-Phospho-Tau [pS262] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyper-phosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. This antibody, combined with Tau [pS356] antibody (44-751),
enables one to distinguish between phosphorylation at the two distinct
residues, rather than a combined epitope as detected by 12E8 antibody. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5021 |
Anti-Phospho-Tau [pS356] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. This antibody, combined with the tau [pS262] antibody
(Cat. # 44-750), enables one to distinguish between phosphorylation at the
two distinct residues, rather than a combined epitope as detected by 12E8
antibody. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5022 |
Anti-Phospho-Tau [pS396] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serine 396 is phosphorylated by GSK-3beta in vitro and in vivo. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5023 |
Anti-Phospho-Tau [pS400] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons that functions to promote
tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serine 400 is phosphorylated by GSK-3beta in vitro and in vivo. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5024 |
Anti-Phospho-Tau [pS404] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons that functions to promote
tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serine 404 is phosphorylated by GSK-3beta and cdk5 in vitro and
in vivo. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5025 |
Anti-Phospho-Tau [pS409] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons that functions to promote
tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serine 409 is phosphorylated by PKA in vitro, and has been shown
to be phosphorylated in AD brain. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5026 |
Anti-Phospho-Tau [pS422] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons and functions to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is
the major component of paired helical filaments (PHF), the building block
of neurofibrillary lesions
in Alzheimer’s disease (AD) brain. Hyperphosphorylated Tau is also found in
neurofibrillary lesions
in a range of other central nervous system disorders. |
polyclonal |
rabbit IgG, affinity-purified |
100 µL |
WB |
| AT-5027 |
Anti-Phospho-Tau [pSpS199/202] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyper-phosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Serines 199 and 202 are phosphorylated by GSK-3b, and have been
linked to hereditary frontotemporal dementia. Serine 202 phosphorylation by
cdk5, stimulated by the presence of microtubules, has been linked to
hereditary neurodegenerative disease. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5016 |
Anti-Phospho-Tau [pT205] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons that functions to promote
tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Microtubule-dependent phosphorylation of threonine 205 is
catalyzed by GSK-3beta and cdk5 in vitro. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB, IHC |
| AT-5017 |
Anti-Phospho-Tau [pT212] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons. The function of tau is to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is the major component of paired helical filaments
(PHF), the building block of neurofibrillary lesions in Alzheimer’s disease
(AD) brain. Threonine 212 is phosphorylated by GSK-3beta, cdk5 and PKA in
vitro and in vivo, and has been shown to be specific for processes found in
neurodegenerative diseases. |
Polyclonal |
rabbit IgG, Affinity-purified |
100 µL |
WB |
| AT-5012 |
Anti-Phospho-Tau [pT217] Polyclonal Antibody |
Phosphorylation site-specific antibody selective for the
phosphorylated form of human tau containing a
phosphate on threonine 217. |
Polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-5019 |
Anti-Phospho-Tau [pT231] Polyclonal Antibody |
Tau is a neuronal microtubule-associated protein found
predominantly on axons and functions to
promote tubulin polymerization and stabilize microtubules. Tau, in its
hyperphosphorylated form, is
the major component of paired helical filaments (PHF), the building block
of neurofibrillary lesions
in Alzheimer’s disease (AD) brain. |
polyclonal |
rabbit IgG, affinity-purified |
100 µL |
WB |
| AT-5005 |
Anti-tau (421/422) Monoclonal Antibody |
This antibody recognizes tau when truncated at Asp421.
Several caspases, including caspase-3, caspase-7,
and caspase-8, cleave tau at this site, yielding the truncated form of the
protein. This antibody does not react with full-length tau, or with tau
truncated at Glu391 or Ala429. |
Tau3 |
Mouse IgG1κ |
50 µg |
WB, IP, IHC |
| AT-5004 |
Anti-Tau (pan) Monoclonal Antibody |
This antibody recognizes proteins of 45-68 kDa, identified
as tau proteins. Tau proteins promote the assembly
of tubulin monomers into microtubules and stabilize microtubules. The TAU-5
monoclonal antibody reacts with the non-phosphorylated as well as the
phosphorylated forms of tau. |
TAU-5 |
Mouse IgG1 |
100 µg |
WB, IP, IHC |
| EP-5031 |
Rabbit Anti-MATH-2 Polyclonal Antibody |
This antibody is specific for the Math2 protein |
Polyclonal |
rabbit IgG |
100 UG |
WB |
| EP-5030 |
Rabbit Anti-YOTIAO/AKAP9 Polyclonal Antibody |
This antibody reacts with the ~230 kDa yotiao protein |
Polyclonal |
rabbit IgG |
100 UG |
WB, ELISA, IP |
| AT-8051 |
Anti-PC-Specific PL-D1, human, internal Polyclonal
Antibody |
Activation of PL-D results in the generation of second
messengers, phosphatidic acid and diglycerides,
and appears to be involved in secretion, vesicle trafficking, mitosis and
meiosis. In leukocytes, PL-D regulates
cytoskeletal-dependent antimicrobial responses such as phagocytosis and
oxidant generation. PL-D1 is regulated
by GTP-binding proteins, (ARF and Rho families) and by protein kinase C. |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-8050 |
Anti-PC-Specific PL-D1, human, N-terminal Polyclonal
Antibody |
This antibody specifically recognizes the N-terminal
region of the PL-D1 enzyme. Activation
of PL-D results in the generation of second
messengers, phosphatidic acid and diglycerides, and appears to be involved in
secretion, vesicle trafficking, mitosis and meiosis. In leukocytes, PL-D regulates
cytoskeletal-dependent antimicrobial responses such as phagocytosis and
oxidant generation. PL-D1 is regulated
by GTP-binding proteins, (ARF and Rho families) and by protein kinase C. |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-8053 |
Anti-PC-Specific PL-D2, mouse, internal Polyclonal
Antibody |
Activation of PL-D results in the generation of second
messengers, phosphatidic acid and diglycerides,
and appears to be involved in secretion, vesicle trafficking, mitosis and
meiosis. In leukocytes, PL-D regulates
cytoskeletal-dependent antimicrobial responses such as phagocytosis and
oxidant generation. The mechanisms
that regulate PL-D2 are not known.
This isoform is unaffected by the activators of PL-D1. |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-8052 |
Anti-PC-Specific PL-D2, mouse, N-terminal Polyclonal
Antibody |
This antibody specifically recognizes the N-terminal
region of the PL-D2 protein. |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-8054 |
Anti-Phospho-Filamin 2 [pS2113] Polyclonal Antibody |
Filamin 2 (FLN2), also
called ABPL (actin-binding protein-like) or gamma-filamin, is a member of a
family of actin binding proteins consisting of filamin
1/alpha-filamin/ABP-280 and
filamin 3/beta-filamin/ABP-278. Filamins are a group of ubiquitous
cytoplasmic phosphoproteins with
molecular weight of approximately 280 kDa that can induce polymerization of
actin filaments. |
polyclonal |
rabbit IgG, Affinity-purified |
10 blot |
WB |
| AT-8055 |
Rabbit ANTI-BETA-CATENIN Polyclonal Antibody |
This
antibody is specific for the ~92 kDa beta-catenin protein |
Polyclonal |
rabbit IgG |
100 UG |
ELISA, IP, WB |
| order |
Product |
Description of antigen |
Clone # |
isotype |
size |
Application |
| Proliferation |
| AT-6005 |
Anti-4E-BP1 Monoclonal Antibody |
Eukaryotic initiation factor 4E binding protein 1
(4E-BP1), also known as PHAS, is a ~20 kDa member
of a family of eIF4E-binding proteins whose binding affinity to eIF4E
is regulated by its phosphorylation. It inhibits cap-dependent translation
by binding to eIF4E on the same site that overlaps the binding site for
eIF4G, preventing its binding to the latter and eventually leading to an
increase in mRNA translation. |
554R16 |
Mouse IgG1κ |
100 µg |
|
| EP-6037 |
Anti-ANGIOPOIETIN 3 (C-TERM) Polyclonal Antibody |
This antibody is specific for the C-terminal region of the
angiopoietin 3 (Ang3) protein |
Polyclonal |
rabbit IgG |
100 UG |
WB |
| EP-6035 |
Anti-ANGIOPOIETIN 3 (N-TERM) Polyclonal Antibody |
This antibody is specific for the N-terminal region of the
angiopoietin 3 (Ang3) protein |
Polyclonal |
rabbit IgG |
100 UG |
WB |
| EP-6036 |
Anti-ANGIOPOIETIN 4 (N-TERM) Polyclonal Antibody |
This antibody is specific for the N-terminal region of the
angiopoietin 4 (Ang4) protein. |
Polyclonal |
rabbit IgG |
100 UG |
WB |
| AT-6001 |
Anti-eIF2alpha Monoclonal Antibody |
This antibody recognizes the a subunit of eukaryotic translation
initiation factor 2 (eIF-2alpha). It is a 36 kDa
protein and is ubiquitously expressed in many cell types. |
EIF2α |
Mouse IgG1 |
0.1 mg |
WB |
| AT-6002 |
Anti-eIF2alpha Polyclonal Antibody |
Eukaryotic initiation factor 2alpha (eIF2alpha) is a 36
kDa, ubiquitously expressed protein.
eIF2alpha, eIF2beta and eIF2gamma comprise the
three subunits of eukaryotic initiation factor (eIF),
a key molecule in the regulation of protein translation. In mammalian
cells, stress
induces the phosphorylation of eIF2alpha at serine 52 by at least two
kinases: the
haem-controlled repressor (HCR) and the interferon inducible double
stranded RNAdependent
protein kinase (PKR). |
Polyclonal |
rabbit IgG |
100 µg |
WB |
| AT-6003 |
Anti-mTOR Polyclonal Antibody |
Mammalian target of Rapamycin (mTOR), also known as
FKBP12-rapamycinassociated
protein (FRAP) is a ~280 kDa serine/threonine
kinase and a key modulator of
cell growth and protein synthesis. mTOR is implicated in cancer and neurite
plasticity,
and plays a central role in mediating phosphoinositide 3-kinase (PI3 kinase)
and
Akt/PKB signals for cell growth, proliferation, and protein translation via
ribosomal S6
kinase (S6Ks) and translation regulator eIF4E-binding protein 1. |
Polyclonal |
rabbit IgG |
